A hallmark of many degenerative and rheumatic diseases is dysregulation of cells’ energy metabolism. Targeting metabolism to increase energy production has been proposed as a direction for therapeutic strategies, but developing a well-controlled system has been challenging. Writing in Nature, Chen et al. isolate a photosynthetic system from plants, encapsulate it in membranes of mammalian cells, and demonstrate light-dependent production of the key metabolites ATP and NADPH after transfer to mammalian cells.
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Cite this articleDoerr, A. Transfer of a plant-derived photosynthetic system to mammalian cells.
Nat Biotechnol 41, 21 (2023). https://doi.org/10.1038/s41587-022-01645-z
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Published: 18 January 2023
Issue Date: January 2023
DOI: https://doi.org/10.1038/s41587-022-01645-z
